Monday, April 28, 2008

Something is not right,wait a minute,a hell lot of things is not right!!

This post is about malignancy,not the malignancy growing in a human's body but a malignancy growing in our society these days. It is disheartening to read the newspaper everyday only to notice more and more unwise policy being implemented. here's some of them
1) To curb rice shortage,eat less rice-very good suggestion indeed. if one day we have fabric shortage,we have to wear less clothings! If water shortage,drink less water! If we have shortage of brain power(brain drain), use less brain!! get the idea?
2) To prevent oversea trained doctors from staying overseas, dun send them overseas-this is another ridiculous suggestion. I remember reading in the past few years, an endocrinologist trained in the prestigious Mayo clinic in the US is denied a job here in Malaysia because he is told he is"overqualified". And now the government is complaining there is shortage of sub specialist because all of them prefer to stay overseas! For heaven's sake, don't these politician have any brains at all? or is their frontal cortex missing?
3)The students did badly in math and science because they are in english. So,convert them back to the Bahasa Malaysia.- so,this is another brilliant suggestion by our beloved education minister. As the saying goes,"if u can't beat them,join them". Really ridiculous. In my time(10 years ago), when the paper is in Bahasa, there is less student who score straight A in UPSR in my school compared to now(when the paper is in English). Moreover, looking at the standard of english among the university students, converting math and science back into BM is like rubbing salt to the wound. only one word: atrocious
4) Angkasawan- ok really,what the hell is the result of the experiments presumably conducted by our very own ANGKASAWAN? I remember them saying "the result will be made public next month"(they said that several month ago). I am really curious about the microbiology experiment,so please someone tell me the results!!
5)Stopping all mega projects in Penang because she is "an opposition state"- come on la, all the states are MALAYSIAN! The federal government seem to think the rakyat will see "tiada kemajuan di bawah pemerintahan DAP di Penang" if they stop the mega projects there. Do you really think the rakyat is that stupid? We have eyes we can see what you are doing! DON't show your hypocrite attitude especially now that 5 states is under the opposition!! Learn your lesson, be fair!

and i recently heard that a junior of mine failed to get his way into Matriculation program although he scored 12A1s in his SPM. Once again, i think he is considered "overqualified":). He opted to do STPM, and i'm sure he will do very well. After all, STPM is recognised worldwide while Matriculation is only useable here in Malaysia. Good luck to you! Hopefully when your turn came to apply for university, you will not be seen as "overqualified"! hehe

I really love my country, so please, someone do something before we turn from a developing country to a poor one. Malaysia memang boleh. Just like a battery that have potential electrical energy in it, so does Malaysia have the potential to develop.BUT,just like the wiring must be correctly connected to the battery in order to light the bulb, likewise Malaysians have to be wise and do correct policy in order to achieve Vision 2020. Malaysia boleh!! come on malaysians buck up!:)

Saturday, April 19, 2008

An introduction to malignancy..from the brain of a MS

Malignancy,neoplasm--> a group of cells with unlimited growth potential and whose growth is uncoordinated with that of normal cells,normally unresponsive to growth inhibitors or excessively responsive to growth factors.

cancer- "crab" due to the uncoordinated growth pattern of malignant tumor resembling the way crabs walk

TUMOR-->a group of cells which grow excessively creating a mass,not necessarily malignant

There are at least7 difference between a benign and malignant tumor

malignant- margins are poorly demarcated,irregular infiltrative growth pattern,usually red and hemorrhagic(angry looking),surface are irregular,able to metastasis,ulceration,capable of invasion

HALLMARKs of neoplasm: GRAAAM
G-self sufficient in GROWTH SIGNAL
R-unlimited REPLICATIVE POTENTIAL
A-abnormal APOPTOSIS(programmed cell death)
A-unresponsive to ANTIGROWTH signal
A-excessive ANGIOGENESIS(blood vessel formation)
M-capable of METASTASIS(spread from 1 organ to the others)

Causes of neoplasm: Physical agent-Radiation,UV light
Chemical agent-nitrites,oxidising agent e.g. Hydrogen peroxide,
Biological agent-virus e.g. HPV type 16 and 18(cervical adenocarcinoma),bacteria e.g. H.pylori(gastric carcinoma),parasite e.g. Schistosoma.haematobium(Urothelioma)

Terminologies:
carcinoma-neoplasm of epithelial tissue
sarcoma-neoplasm of connective tissue
adenocarcinoma-carcinoma with glandular pattern of cell arrangement
squamus cell carcinoma-carcinoma with squamus(layered) pattern of cell arrangement

benign tumor is recognised by adding -oma to the word,e.g. lipoma(benign growth of the fat tissue),angioma(benign growth of vessels)
However there are exceptions-->e.g.lymphoma(malignant growth of the lymphoid cells),astrocytoma(malignant growth of astrocytes),ependymoma(malignant growth of ependymal cells)

some special names--> leukemia(cancer of white blood cells),carcinomatosis peritonei(advanced stage of cancer involving the whole peritoneum),carcinomatosis cerebri(involving whole cranium),pseudomyxoma peritonei(excessive accumulation of mucin in peritoneum now thought to most likely originate from a appendicical tumor),struma ovarii(presence of foreign tissue e.g. thyroid in the ovary)

in the next post, the neoplasm that i am most familiar with will be discussed. Although this tumor is very very very rare, it happens,to my mum. The one cancer which killed her: Duodenojejunal adenocarcinoma leading to carcinomatosis peritonei. stay tune!

Hello

this page is created to explain about the various type of cancer,share experience regarding cancer,and of course to enable me to use my time usefully(rather than playing jedi everyday).